Large granular lymphocyte leukemia (LGL) in a child with hyper IgM syndrome and autoimmune hemolytic anemia
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چکیده
منابع مشابه
Concurrent Atypical Hemolytic Uremic Syndrome and Autoimmune Hemolytic Anemia: a case report
Background: Atypical hemolytic uremic syndrome (aHUS) is a life-threatening and scarce disorder characterized by acute renal failure and disease, non-immune microangiopathic hemolytic anemia and thrombocytopenia, leading to end-stage renal failure or death, and consequently maybe accompanying by extra renal manifestations. Case report: We reported aHUS accompanied by autoimmune hemolytic anemi...
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Background Autoimmune hemolytic anemia is a hematologic disorder that is rarely observed in infants and young children. Most of the cases are associated with viral or bacterial infections. In some cases, AIHA can be characterized by a chronic course and an unsatisfactory control of hemolysis, thus requiring prolonged immunosuppressive therapy. Case report Especially in children younger...
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We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly normal directly after reconstitution. However, there was a slower reconstitution after the second ritu...
متن کاملSuccessful treatment of IgM-mediated autoimmune hemolytic anemia with bortezomib.
Chronic cold agglutinin disease (CAD) is an acquired autoimmune hemolytic anemia (AIHA); usually due to the production of a monoclonal immunoglobulin M (IgM) protein directed against polysaccharide antigens on red blood cells.1,2 An occult lymphoproliferative disorder is often responsible for the production of the IgM paraprotein in patients with symptomatic CAD.3 The discovery of an underlying...
متن کاملLarge granular lymphocyte leukemia.
Clonal diseases of large granular lymphocytes (LGLs) represent a spectrum of clinically rare lymphoproliferative malignancies arising from either mature T-cell (CD3(+)) or natural killer (NK)-cell (CD3(-)) lineages. The clinical behavior of these disorders ranges from indolent to very aggressive. Patients with symptomatic indolent T-cell or NK-cell LGL leukemia are usually treated with immunosu...
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ژورنال
عنوان ژورنال: Pediatric Blood & Cancer
سال: 2008
ISSN: 1545-5009,1545-5017
DOI: 10.1002/pbc.20902